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These may include integrating ferroptosis inducers with immune checkpoint blockade, pairing oncolytic virotherapy with phagocytosis-enhancing agents such as CD47 inhibitors, or incorporating autophagy inhibitors into chemoradiation regimens for selected molecular subtypes
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This makes it part of a unique class of peptides called mitochondrial-derived peptides (MDPs) small proteins that act as signaling molecules to regulate metabolism and cellular stress responses
doi: 10.1016/j.molimm.2012.08.005
