l-carnitine side effects fishy odor tmao heart disease The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney Revisiting the Role of Carnitine

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A 2024 study in dexamethasone-induced NASH rats demonstrated that L-carnitine restored Akt phosphorylation, inhibited FOXO1 nuclear translocation, and downregulated autophagy and apoptosis markers (LC3, P62, caspase-3, p-MLKL) via the Akt/FOXO1 pathway (59)

and Carmichael, S.W

Longitudinal monitoring Given the significant cardiovascular and renal associations, it would be interesting to follow patients with serial TMAO measurements and serial echocardiography or renal function measurements to evaluate their correlation in real-world patients