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2 Minimal criteria suggestive for clEDS consist of all three major criteria

These studies have included a diverse range of drugs, such as cisplatin, carboplatin, 5-fluorouracil, paclitaxel, bleomycin, doxorubicin and etoposide (74,80,81)

Cell Tissue Res 368:371378

Spacing dose increases by the recommended protocol (typically one week minimum) gives your body adequate time to adapt before introducing higher receptor activation
