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Several biofilm evasion strategies have been found in the innate immunity including reductions in TNF-, IL-1 beta (IL-1), CXC Motif Chemokine Ligand 2 (CXCL2), and CC Motif Chemokine Ligand 2 (CCL2) formation that limited macrophage invasion into the biofilm

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The study further suggests that a combination of targeted intervention strategies, involving the modulation of glutamine metabolism, has the potential to reshape the immune microenvironment and enhance the efficacy of CAR-T cell therapy