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Serotoninnorepinephrine reuptake inhibitors for pain control: premise and promise

The most severe reactions reported to have occurred with overdose of trazodone hydrochloride tablets alone have been priapism, respiratory arrest, seizures, ECG changes, including QT prolongation and syndrome of inappropriate antidiuretic hormone secretion (SIADH)

Hydroxocobalamin is administered intramuscularly, bypassing gastrointestinal absorption and entering the bloodstream rapidly
