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Peripheral T cells infiltrated the lesion site after an IS and aggravated BBB injury (55)
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In addition, the role of the ECM in regulating the stem cell niche needs to be more extensively explored
for example, the TLR4/NF-B/IL-1 signaling pathway is activated in chronic SZ patients (197), and clozapine reduces the expression of pro-inflammatory genes such as IL-1 and IL-6 by inhibiting the TLR4/NF-B pathway (198)
