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Silencing of glutamate-cysteine ligase (GCLC), a rate-limiting enzyme in GSH biosynthesis, caused an increase in oxidative stress/protein oxidation and downregulation of the the CYP2R1 , CYP27A1 , CYP27B1 , VDBP , and VDR genes in cultured hepatocytes

Originally developed as anti-epileptic medications, gabapentinoids have become widely used for the treatment of neuropathic pain and a range of other conditions

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