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Diabetes 58 , 299301 (2009)

penetration-enhanced preparations (including palmitoylated versions such as Pal-GHK) are needed for meaningful dermal delivery Injectable advantages: bypasses the skin barrier entirely, delivers GHK-Cu systemically, and can be combined in the same protocol as BPC-157 and TB-500 for comprehensive wound care The distinction between topical and injectable GHK-Cu is clinically important and is not simply a matter of convenience

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This, in turn, enhances the drug efficacy while reducing the risk of systemic toxicity, as it helps prevent rapid burst release and minimizes the need for repeated dosing (Natarajan et al., 2014