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This cytokine shift, which enhances antiviral and antitumor immune responses, which are critical for the elderly to fight age-associated diseases, is linked to an increase in NK cell numbers, potentially explaining the enhanced IFN- production [212]

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However, the production of various ROS in excess of endogenous antioxidant defense mechanisms promotes the development of a state of oxidative stress, with significant biological consequences

However, FOXO1 inhibition reduced the viability of all tested cell lines, particularly cells with lower nuclear FOXO1, including KRAS wild-type cells (Appendix Fig