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Experiments were repeated three times independently, with similar results ( b, e )

(9) an alternative mechanism of action of FB1 involves the disruption of the de novo sphingolipid biosynthesis pathway by inhibition of the enzyme ceramide synthase [68, 112]

Conclusions The compounds that are able to reduce toxic effects exerted by BaP act through various mechanisms: Decrease of AhR translocation (e.g., resveratrol, curcumin) Downregulation of Cyp 450 level and other proteins involved in BaP metabolism (e.g., resveratrol, curcumin) Decrease of BPDA-DNA adducts and other DNA damage formation (e.g., curcumin

Moreover, as most phenols in nature are in the form of glycosides, they usually have poor liposolubility, decreasing their transport through membranes