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Our finding that several diseases show lowered blood NAD + levels and overall imbalanced redox metabolites is intriguing, as it suggests that a variety of disease processes increase NAD + usage, potentially by activated repair processes including PARP enzymes a major user of NAD +8 .The results have high potential relevance for clinical and research applications, follow-up of metabolic interventions and detection of disease-induced NAD + or glutathione deficiency to select patients for treatment

[DOI] [Google Scholar] 45.Assimakopoulos S.F., Aretha D., Komninos D., Dimitropoulou D., Lagadinou M., Leonidou L., et al

102 GuoM.ChenY.ChenQ.GuoX.YuanZ.KangL.et al (2020)

Chuang A, Chen Y-L, Nguyen HT, Lu H-T, Liu C-H