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doi: 10.1016/j.trci.2018.11.001 119 GunesS.AizawaY.SugashiT.SugimotoM.RodriguesP

Mesenchymal stem cells (MSCs) are a typical immunosuppressive cell type that can enhance glucose metabolism under inflammation and inhibit T cell function through the JAK/STAT1 pathway by producing IDO, which decomposes tryptophan (64)

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As diabetic nephropathy rats received streptozotocin (60 mg/kg, i.p), daily treatment with two dose levels of ethanolic extract of leaf Artemisia vulgaris (EEAV) showed a significant dose-dependent decrease in various renal function parameters like urinary albumin excretion rate (UAER), type IV collagen excretion, total proteins in urine, creatinine, advanced glycation end products, excretion of glycosaminoglycans and a significant increase in urinary creatinine, glycosaminoglycans, urine volume