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Consequently, the destructive pathway of macrophage/-cell communication would be inhibited, the perpetuation of -cell destruction prevented, and anti-inflammatory pathways conducive with preservation of -cell function and mass, and disease prevention, would prevail

Reduced GCLC promoter activity from this variant produces a lower basal GCLC enzyme pool constraining the rate of -GluCys synthesis from the transcriptional level, upstream of any allosteric or substrate-availability-related regulation

Acknowledgements The authors express their gratitude to Maida Lekovic, Nerkeza Drekovic, and Nithad Granica for their technical support throughout the experiment, as well as to assistant professor Kimeta Hamidovic for proofreading the manuscript in English

Introduction If you have spent any time exploring the world of wellness, you have likely seen two ingredients appearing on almost every shelf: L-glutamine and L-glutathione