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Notably, thioredoxin reductase (TrxR) can reduce oxidized forms of glutaredoxins (Grx) and GPx, both of which depend on GSH for their redox activity [44]
Through this machinery, monocytes upregulate MCT4 while downregulating LDH and MCT1, reflecting enhanced capacity for lactate handling during inflammation 48
Our observation of CBS filaments with heterogeneous lengths in cryo-EM micrographs, therefore, sufficiently explains previous findings of a mixture of CBS oligomers
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