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All fat cells release hormones, but because visceral fat is stored next to your organs, its more likely to interfere with organ functions, which can lead to greater insulin resistance (type 2 diabetes), higher blood pressure, higher bad cholesterol (LDL) levels in your blood stream, and increase risk for heart disease and stroke
This indicates that apoC1 in macrophages is not likely to play a major role in the development of atherosclerotic plaques in vivo, despite its promoting effect on cholesterol efflux demonstrated in vitro
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