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oryzae M-23, which is auxotrophic for arginine (knockout of argB )
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Case-fatality rates for RMSF were as high as 6580% prior to antibiotics 3 and can be fatal even after antibiotic treatment 4

Nave T cells rely primarily on oxidative phosphorylation to generate ATP, whereas activated T cells shift their metabolism toward aerobic glycolysis (Warburg effect) to meet the demands of growth, proliferation, and effector functions, such as IFN- production (136)