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intracellular glutathione levels A Activatable Ion Channel Induces Apoptosis in Cancer Cells by Depleting Glutathione - Malla - 2020 - Angewandte Chemie International Edition Stimulation of de novo glutathione
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M.MyersV

doi:10.1074/jbc.M602999200 pmid:16624800 Ferreira DG, Batalha VL, Vicente Miranda H, Coelho JE, Gomes R, Gonalves FQ, Real JI, Rino J, Albino-Teixeira A, Cunha RA (2017) Adenosine A2A receptors modulate -synuclein aggregation and toxicity

This dependency renders cells sensitive to fluctuations in extracellular cystine supply and positions system xc as a key metabolic checkpoint linking nutrient availability to oxidative stress responses and ferroptotic susceptibility
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