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Drug Repurposing: Clinical evaluation of Deferiprone (an iron chelator, NCT04178850) in COPD patients with evidence of iron dysregulation could validate the role of iron in disease pathogenesis and treatment

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SHMT1-mediated metabolism also influences the ability of tumor cells to synthesize crucial lipids, like sialic acid N-acetylneuraminic acid, which supports the release of cytokines (IL-6 and IL-8) involved in ovarian cancer cells proliferation and migration in mouse models [119]

These mutants also accumulated higher levels of protein carbonyls and peroxidated lipids during aging [16], [17], suggesting that antioxidant defenses were compromised by the loss of clock function