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These results suggest that the neuroprotective mechanism of nicotine may be directly or indirectly connected to the nAChR up-regulation in cerebral cortical blood flow (Linville et al., 1993)
PMC 3549305

In particular, the study revealed that individuals who received a daily evening dose of 0.15 mg of melatonin per kg of body weight over six consecutive months exhibited CSF levels of tau proteins compared to those treated with a placebo [127]

The l-cysteine desulfhydrase of Escherichia coli