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Consequently, M2-type TAMs within the TIME facilitate iron transport to the extracellular environment, suppress recruitment and cytotoxic function of tumoricidal immune cells, stimulate angiogenesis, and enhance tumor cell proliferation, invasion, and metastasis

In contrast, ET had no significant effect on the expression of UPR target genes in primary mouse embryonic fibroblasts (Figure S1B)

This disruption in signaling pathways is a critical factor in tumor formation (Yewale et al., 2013), particularly in lung cancer, where EGFR plays a vital role (Peifer et al., 2012)

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