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These pre-clinical studies attributed the recovery in symptom profile to modulation of glucose transport, over-expression of mitochondrial genes, bypassing defective pathways of ETC (electron transport chain), and improvement in mitochondrial biosynthesis, modulation of microbiota, regulation of brain neuronal networks, and promoting synthesis of white matter in the brain [168]

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The evidence consistently demonstrates that semaglutide is generally well-tolerated, with side effects that are predominantly gastrointestinal, mild-to-moderate in severity, transient in duration, and manageable through evidence-based strategies