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Because many imaging modalities rely on electromagnetic radiation to generate signals (for example, optical and optoacoustic imaging, computed tomography and positron emission tomography), this phenomenon can be used to both activate a drug and monitor tissue response, creating a theranostic synergy

It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models

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