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Clinical Criteria for approval To reduce excess body weight and maintain weight reduction in combination with current and ongoing lifestyle modification including structured nutrition and physical activity consistent with the applicable FDA approved label AND At least 18 years of age and has a BMI (body mass index) greater than or equal to 35 at the time of initiation of GLP-1 therapy OR At least 18 years of age and BMI greater than or equal to 30 at the time of initiating GLP-1 therapy with a diagnosis of one or more of the following: heart failure with preserved ejection fraction uncontrolled hypertension (defined as systolic blood pressure above 140 mm Hg or diastolic blood pressure above 90 mm Hg chronic kidney disease stage 3a or above OR At least 18 years of age and BMI greater or equal to 27 at the time of initiating GLP-1 therapy with a diagnosis of one or more of the following: pre-diabetes (as defined by American Diabetes Association guidelines) previous myocardial infarction previous stroke symptomatic peripheral artery disease

373 In fact, when BMSCs are exposed to exendin-4, the expression of genes related to bone development factors such as Runx and Osterix, as well as genes responsible for producing the bone matrix such as Balp and Bglap, is upregulated

CRLB, Cramer-Rao lower bounds