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Sleep, insomnia, and depression

KPV: Anti-Inflammatory Tripeptide Research Guide KPV is a tripeptide (lysine-proline-valine) derived from the C-terminal of alpha-MSH

Using pharmaceutical-grade peptides, rotating injection sites, and staying hydrated can also minimize unwanted effects

The finding that sleep deprivation leads to lower cortisol levels post deprivation (primarily during the subsequent night of sleep) suggests that lowering the level of HPA activity, which is increased in depression, may be the mechanism through which sleep deprivation improves the mood of depressed individuals
