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Iron mediates endothelial cell damage and blood-brain barrier opening in the hippocampus after transient forebrain ischemia in rats

Sci Signal 3: ra52, 2010 [DOI] [PMC free article] [PubMed] [Google Scholar] 173.Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, Palliyaguru DL, Fujimuro M, Boley PA, Tanaka Y, Shigemura N, Biswal S, Yamamoto M, and Kensler TW

Subjects/Methods: A 1-month pilot clinical study of oral liposomal GSH administration at two doses (500 and 1000 mg of GSH per day) was conducted in healthy adults

In contrast, newer clinical compounds such as Molidustat (BAY 85-3934) were developed with improved selectivity toward distinct PHD enzymes and optimised pharmacological properties 15
