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Another major obstacle to translation is the continued reliance on diagnostic categories, disregarding the considerable pathophysiological and phenomenological heterogeneity in SSD

Future research will likely focus on the specific regulatory mechanisms of these metabolic processes in different neuronal populations, such as the lactate shuttle pathway and monocarboxylate transporter (MCT)-mediated interactions, how they are involved in the pathological processes of neurodegenerative diseases through key signaling pathways, and how to target specific metabolic enzymes and transporters for therapeutic intervention (Blanger et al., 2011)

17%) and moderate dd-cfDNA (5 in 43 cases

L., Goldman, Y