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Trivedi MS, Holger D, Bui AT et al (2017) Short-term sleep deprivation leads to decreased systemic redox metabolites and altered epigenetic status

The death of AECs not only compromises the alveolar barrier, resulting in alveolar collapse and impaired gas exchange, but also promotes the release of pro-inflammatory mediators and cellular debris, which further activate alveolar macrophages and fibroblasts, exacerbating local inflammation and fibrotic remodeling (Liu et al., 2022c)

Second, many available studies are characterized by small sample sizes or lack appropriate control groups, making it difficult to draw definitive conclusions about therapeutic efficacy and optimal treatment protocols

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