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Cobalt is required by rumen microbes to synthesise Vitamin B12 without a good source of Cobalt in pasture and grain, Vitamin B12 deficiency can result

The search strategy was developed using keywords and Boolean operators such as rumen-protected methionine, methionine supplementation AND dairy cows, and methionine supplementation AND beef cattle. After retrieval, duplicate records, in vitro studies, literature reviews, and meta-analyses were removed

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Some patients may require an even higher dose of 2 mg weekly for optimal effect, particularly for weight management indications, though this should be approached cautiously with careful monitoring for adverse effects