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Arch Gynecol Obstet 284:14431448 Vigerust NF, Bohov P, Bjorndal B, Seifert R, Nygard O, Svardal A, Glintborg D, Berge RK, Gaster M (2019) Acylcarnitines in obese PCOS and effect of pioglitazone

Notably, lutein-only supplementation has shown significant improvements in MPOD and CS, whereas combined lutein and PUFA supplementation showed less pronounced effects [144]

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Key challenges The lack of reliable biomarkers: Because dormant tumor cells cannot be visualized by conventional methodologies such as histopathology or standard imaging modalities, the identification and validation of robust, specific biomarkers are critical.120,166 Drug resistance: Dormant tumor cells are arrested in the G0/G1 phase of the cell cycle, and their basal metabolism is markedly reduced, allowing them to evade therapies that target proliferating cells