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Description
In the late stage of sepsis, macrophages will release high mobility group protein B1 (HMGB1), which can stimulate the expression of Sesn2 in DCs (82)
Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, et al
Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage
The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable
