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Most neurodegenerative diseases are characterized by the deposition of misfolded proteins (e.g., -synuclein, -amyloid, huntingtin) and degeneration of brain networks (Vaquer-Alicea and Diamond 2019)

The observed mitochondrial alterations are the suppression of the PDC, thereby lowering the conversion of pyruvate to acetyl-CoA and diminished mitochondrial ATP production from OXPHOS and glycolysis

10.1016/j.fas.2019.03.010 71 RibitschI.BileckA.AldoshinA