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Replacing the bromine with a hydroxyl group (ENDO13) and introducing a phenylacetamide (ENDO11) at the diethylamino end of ENDO3 did not result in activity improvement (Fig

Common nonsteroidal antiinflammatory drugs (NSAIDs) (eg, celecoxib) inhibit transport by MRP4, which may contribute to renal toxicity when a cytotoxic agent such as methotrexate is coadministered with NSAIDs (El-Sheikh et al, 2007)

An atom of iron at the center of the heme group plays a central role in the process, flipping between the ferrous (Fe++) and ferric (Fe+++) states as a result of the movement of electrons through it

17 The tardigrade damage suppressor protein (Dsup) binds to nucleosomes, protecting chromosomes from reactive hydroxyl radicals that damage DNA