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Given the significant role of lipid metabolism in supporting tumor progression and reshaping the tumor microenvironment, targeting lipid metabolic pathways may offer new avenues for cancer therapy ( 6 Future directions This review briefly discusses the role of ubiquitination and deubiquitination in cancer lipid metabolism, highlighting how E3 ligases and DUBs participate in lipid synthesis, cholesterol synthesis, transcriptional reprogramming, and lipid homeostasis by regulating metabolic enzymes, transcription factors, and related signaling pathways

(Basel) 13 (12), 961