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Convergent mechanismsoxidative stress, mitochondrial insufficiency, cellular senescence, immunosenescence with low-grade inflammation, and disrupted cholinergic/catecholaminergic signalingjointly depress tear volume and alter composition

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This variation in pO2, in particular, differentially regulates the compartmentalization and functioning of the transcription factors hypoxia-inducible factor-1 (HIF-1) and nuclear factor-B (NF-B)
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