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In a previous study, transcriptomic profiling of brain regions involved in the brains reward circuitry (prefrontal cortex, dorsal striatum, nucleus accumbens, basolateral amygdala, ventral hippocampus, and ventral tegmental area) revealed considerable changes in transcript expression during the cocaine self-administration, withdrawal, and relapse phases, with the greatest changes detected in the re-exposure phase 40

On the other hand, the log 2 FC values were also positive for 164 compounds (97 metabolites and 67 drugs/xenobiotics), suggesting an increase in extracellular concentration due to the export or antiport of yeast metabolites or enzymatic activity on serum compounds (Figure 2B)

J Endocrinol 107 , 183189 (1985)